8 research outputs found
The MeSH-gram Neural Network Model: Extending Word Embedding Vectors with MeSH Concepts for UMLS Semantic Similarity and Relatedness in the Biomedical Domain
Eliciting semantic similarity between concepts in the biomedical domain
remains a challenging task. Recent approaches founded on embedding vectors have
gained in popularity as they risen to efficiently capture semantic
relationships The underlying idea is that two words that have close meaning
gather similar contexts. In this study, we propose a new neural network model
named MeSH-gram which relies on a straighforward approach that extends the
skip-gram neural network model by considering MeSH (Medical Subject Headings)
descriptors instead words. Trained on publicly available corpus PubMed MEDLINE,
MeSH-gram is evaluated on reference standards manually annotated for semantic
similarity. MeSH-gram is first compared to skip-gram with vectors of size 300
and at several windows contexts. A deeper comparison is performed with tewenty
existing models. All the obtained results of Spearman's rank correlations
between human scores and computed similarities show that MeSH-gram outperforms
the skip-gram model, and is comparable to the best methods but that need more
computation and external resources.Comment: 6 pages, 2 table
Accurate Keyphrase Extraction from Scientific Papers by Mining Linguistic Information
International audienc
Exon discovery by genomic sequence alignment
Morgenstern B, Rinner O, Abdeddaïm S, et al. Exon discovery by genomic sequence alignment. Bioinformatics. 2002;18(6):777-787.Motivation: During evolution, functional regions in genomic sequences tend to be more highly conserved than randomly mutating 'junk DNA' so local sequence similarity often indicates biological functionality. This fact can be used to identify functional elements in large eukaryotic DNA sequences by cross-species sequence comparison. In recent years, several gene-prediction methods have been proposed that work by comparing anonymous genomic sequences, for example from human and mouse. The main advantage of these methods is that they are based on simple and generally applicable measures of (local) sequence similarity; unlike standard gene-finding approaches they do not depend on species-specific training data or on the presence of cognate genes in data bases. As all comparative sequence-analysis methods, the new comparative gene-finding approaches critically rely on the quality of the underlying sequence alignments. Results: Herein, we describe a new implementation of the sequence-alignment program DIALIGN that has been developed for alignment of large genomic sequences. We compare our method to the alignment programs PipMaker, WABA and BLAST and we show that local similarities identified by these programs are highly correlated to protein-coding regions. In our test runs, PipMaker was the most sensitive method while DIALIGN was most specific